Introduction

The antimicrobial properties of silver have been known to cultures all around the world for many centuries. The Phonecians stored water and other liquids in silver coated bottles to discourage contamination by microbes (Wikipedia: Silver). Silver dollars used to be put into milk bottles to keep milk fresh, and water tanks of ships and airplanes that are „silvered“ are able to render water potable for months (Saltlakemetals.com). In 1884 it became a common practice to administer drops of aqueous silver nitrate to newborn’s eyes to prevent the transmission of Neisseria gonorrhoeae from infected mothers to children during childbirth (Silvestry-Rodriguez et al., 2007).

In 1893, the antibacterial effectiveness of various metals were noted and this property was named the oligodynamic effect. It was later found that out of all the metals with antimicrobial properties, silver has the most effective antibacterial action and the least toxicity to animal cells (Guggenbichler et al., 1999). Silver became commonly used in medical treatments, such as those of wounded soldiers in World War I, to deter microbial growth (Saltlakemetals.com).

Once antibiotics were discovered, the use of silver as a bactericidal agent decreased. However, with the discovery of antibiotics came the emergence of antibiotic-resistant strains such as CA-MRSA and HA-MRSA, the flesh-eating bacteria. Due to increasing antibiotic resistance, there has recently been a renewed interest in using silver as an antibacterial agent. The availability of new laboratory technologies such as radioactive isotopes and electron microscopy has greatly enabled us to investigate the antibacterial mechanism of silver in recent years (Fox and Modak, 1974; Feng et al., 2000).

Mechanism of action

Protein inactivation

Although the antimicrobial properties of silver have been known for centuries, we have only recently begun to understand the mechanisms by which silver inhibits bacterial growth. It is thought that silver atoms bind to thiol groups (-SH) in enzymes and subsequently cause the deactivation of enzymes. Silver forms stable S-Ag bonds with thiol-containing compounds in the cell membrane that are involved in transmembrane energy generation and ion transport (Klueh et al., 2000). It is also believed that silver can take part in catalytic oxidation reactions that result in the formation of disulfide bonds (R-S-S-R). Silver does this by catalyzing the reaction between oxygen molecules in the cell and hydrogen atoms of thiol groups: water is released as a product and two thiol groups become covalently bonded to one another through a disulfide bond (Davies and Etris, 1997). The silver-catalyzed formation of disulfide bonds could possibly change the shape of cellular enzymes and subsequently affect their function.

The silver-catalyzed formation of disulfide bonds can lead to changes in protein structure and the inactivation of key enzymes, such as those needed for cellular respiration (Davies and Etris, 1997). 30S ribosomal subunit protein, succinyl coenzyme A synthetase, maltose transporter (MalK), and fructose bisphosphate adolase were identified with high probability as proteins with decreased expression once cells are treated with a 900 ppb Ag⁺ solution (Yamanaka et al., 2005; Figure 2). It is hypothesized that silver ions bind to the 30S ribosomal subunit, deactivating the ribosome complex and preventing translation of proteins (Yamanaka et al., 2005). The proteins that were found to be downregulated upon treatment with Ag⁺ serve important functions to the cell: succinyl-coenzyme A synthetase, an enzyme involved in the TCA cycle, catalyzes the conversion of succinyl-CoA to succinate while phosphorylating ADP to produce ATP (Slonczewski and Foster, 2009); fructose bisphosphate adolase is an enzyme involved in glycolysis that catalyzes the breakdown of fructose-1,6-bisphosphate into glyceraldehydes 3-phosphate and dihydroxyacetone phosphate (Slonczewski and Foster, 2009); MalK is a cytoplasmic membrane-associated protein involved in the transport of maltose (Bavoil et al., 1980). In one way or another, all of these proteins play a role in energy and ATP production for the cell, so the decreased expression of any one of these proteins could lead to cell death (Yamanaka et al., 2005).

DNA association

Another one of the suggested mechanisms of the antimicrobial activity of silver was proposed by Klueh et al., (2000). It was proposed that Ag⁺ enters the cell and intercalates between the purine and pyrimidine base pairs disrupting the hydrogen bonding between the two anti-parallel strands and denaturing the DNA molecule (Klueh et al., 2000). Although this has yet to be proved, it has been shown that silver ions do associate with DNA once they enter the cell (Fox and Modak, 1974).

Entering the cell

Most of the proposed mechanisms involve silver entering the cell in order to cause damage. How would a metal like silver, or its ionized form Ag⁺, get across the hydrophobic cellular membrane to access the cytoplasm? From the perspective of a transmembrane protein, the silver ion simply appears to be a particle of certain size with a +1 charge. It is possible that silver ions get access to the interior of cells through transmembrane proteins that normally function to transport ions other than silver ions. Transmembrane proteins such as CopB-ATPase from Enterococcus hirae have been shown to be able to transport silver ions although its putative function is a copper transporter (Solioz and Odermatt, 1995). This proves that there are ways for silver to be transported across the cell membrane even though specific silver transporters may not exist.

Ionized silver

In order for silver to have any antimicrobial properties, it must be in its ionized form (Lok et al., 2007; Rai et al., 2009). Silver in its non-ionized form is inert (Guggenbichler et al., 1999), but contact with moisture leads to the release of silver ions (Radheshkumar and Munstedt, 2005). Thus, all forms of silver or silver containing compounds with observed antimicrobial properties are in one way or another sources of silver ions (Ag⁺); these silver ions may be incorporated into the substance and released slowly with time as with silver sulfadiazine, or the silver ions can come from ionizing the surface of a solid piece of silver as with silver nanoparticles.

Observed effects of silver exposure

Feng et al. (2000) conducted a study to observe the effects of silver ions on gram-positive and gram-negative bacteria, namely Staphylococcus aureus and Escherichia coli. They treated cells with AgNO₃, which is a source of Ag⁺ in aqueous environments, and looked at the structural and morphological effects of these silver ions on the cells. The cells were exposed to AgNO₃ for 4-12 hours before being prepared for microscopy. The cell were then fixed and sliced with an ultramicrotome to produce ultrathin sections for transmission electron microscopy (TEM). They observed that cells exposed to the Ag⁺ ions seemed to have activated a stress response that led to the condensation of DNA in the center of the cell. They also observed cell membrane detachment from the cell wall, cell wall damage, and electron dense granules outside and, in some instances, inside the cell (Figure 3). It was proposed that condensation of DNA occurred as a protective measure in order to protect the genetic information of the cell (Feng et al., 2000), however condensation of DNA could also prevent cell replication by preventing the DNA from being accessed by transcriptional enzymes such as DNA polymerase. The electron dense granules that formed inside and outside the cell were extracted and subjected to X-ray microanalysis to determine their composition. It was discovered that the granules were in part composed of silver and sulfur. This finding supports the idea that silver inactivates proteins by binding to sulfur-containing compounds (Klueh et al., 2000). It was also observed that when treated with Ag⁺, E. coli, a gram-negative bacterium, sustained more structural damages than the gram-positive S. aureus (Feng et al., 2000).

It has also been shown that treating cells with silver leads to cell shrinkage and dehydration (Figure 4) (Guggenbichler et al., 1999). The TEM images from Feng et al. (2000) (Figure 4) show that cells that sustained extensive damage eventually ended up with cell wall and cell membrane damage. Damage to the cell membrane could lead to the leaking of cytoplasm from the cell, which would result in dehydrated and shrunken cells as shown by the SEM images from Guggenbichler et al. (1999).

Attack on Gram-positive vs. Gram-negative

There are two explanations as to why gram-positive bacteria are less susceptible to Ag⁺ than gram-negative bacteria. The first involves the charge of peptidoglycan molecules in the bacterial cell wall. Gram-positive bacteria have more peptidoglycan than gram-negative bacteria because of their thicker cell walls, and because peptidoglycan is negatively charged and silver ions are positively charged, more silver may get trapped by peptidoglycan in gram-positive bacteria than in gram-negative bacteria (Kawahara et al., 2000). The decreased susceptibility of gram-positive bacteria can also simply be explained by the fact that the cell wall of gram-positive bacteria is thicker than that of gram-negative bacteria.

Silver sulfadiazine

Fox and Modak (1974) explored the mechanism of prevention of burn wound infections by silver sulfadiazine. At the time of publication, it had been known for quite a while that silver sulfadiazine (Figure 5) delivered in the form of a topical cream was effective at preventing infections in burn wounds, however it was not known if the antimicrobial activity was due entirely to the silver ions or if the sulfadiazine anion also contributed to the bactericidal effect. Tests from the study showed that sulfadiazine from silver sulfadiazine does not get transported into cells as much as silver. Silver isotopes (¹¹⁰Ag⁺) were also used to show that silver ions that enter cells complex with DNA. Additionally, the rate at which certain silver containing compounds release silver ions into solution was measured by adding silver compounds to human serum and measuring the amount of unreacted silver compound with increasing time (Figure 6). Notice in Figure 6 how silver sulfadiazine (Ag sulfadiazine) gradually releases the majority of its silver ions into solution over an extended period of time whereas silver nitrate immediately released all of its silver ions into solution (Fox and Modak, 1974). Therefore, silver sulfadiazine’s effectiveness as an antimicrobial agent for preventing burn wound infections is due to its tendency to dissociate in solution: silver sulfadiazine provides a steady supply of silver ions over a long period of time where as other silver salts such as silver nitrate release a large amount of silver ions all at once. If silver is employed as the primary antimicrobial agent in burn wound creams, the burn wound needs a steady supply of silver ions over a long period of time to kill off any microbes that could possibly infect the wound until it heals. Compounds that release silver ions all at once would need to be applied very frequently in order to kill off invading bacteria and prevent infection, and sometimes highly frequent application isn’t always practical or possible for individuals, so compounds that constantly release a bactericidal amount of silver ions, such as silver sulfadiazine, are the most effective at preventing burn wound infections.

It has also been shown that when silver treatment is combined with other antimicrobial methods such as UV light, copper ions, or oxidizers, a synergistic effect is observed, that is bacterial growth is inhibited more by treatment with silver and an additional antimicrobial method than would be expected if the inhibition effects of silver and that additional antimicrobial method were summed (Silvestry-Rodriguez et al., 2007). Because silver can inflict a fair amount of damage to the cell only once it gains access to the cytoplasm, it is believed that if some other antimicrobial method can give silver ions access to the cytoplasm sooner than if silver ions were working alone, a synergistic effect of the two methods would be observed (Silvestry-Rodriguez et al., 2007).

Different forms effective at microbial inhibition

Silver salts

Silver can be administered to cells in a various number of ways. Silver salts such as silver nitrate (AgNO₃) are effective at providing a large quantity of silver ions all at once. Because silver binds to thiol groups, it has been proposed that although one of the antimicrobial mechanisms of Ag⁺ is binding to sulfur-containing compounds, thiol-containing compounds such as proteins with cysteine residues can also serve to absorb the silver ions and neutralize their antibacterial activity by preventing the silver ions from attacking DNA (Liau et al., 1997). For this reason, prolonged antimicrobial activity from silver is best achieved by continuously releasing a moderate amount of silver ions.

Silver zeolite

Silver zeolite is also a commonly used form of antibacterial silver. Zeolite (Figure 7) is a porous matrix of sodium aluminosilicate that can bind a large amount of silver ions in its micropores (Monteiro et al., 2009). Silver ions are released from the zeolite matrix by exchange with other cations in solution and the amount released is proportional to the concentration of other cations in the solution (Breck, 1974 as cited in Kawahara et al., 2000). Kawahara et al., (2000) ran experiments to test the antimicrobial properties of silver zeolite in anaerobic conditions. Minimum inhibitory concentration (MIC) assays were performed using silver zeolite, and it was found that depending on the species tested, the minimum inhibitory concentrations of silver zeolite ranged from 256 to 2048 µg/ml, which corresponded to a range of 4.8 to 38.4 µg/ml of Ag⁺. Because zeolite is already used in some toothpastes as a polishing material and the lack of silver toxicity to humans at concentrations such as those found in the MIC assays, the authors believed that silver zeolite would be a good compound to incorporate into dental materials, even those used in anaerobic conditions such as in periodontal pockets (Kawahara et al., 2000).

Silver nanoparticles

Silver nanoparticles have been heavily studied as antimicrobial materials. Their simple synthesis (Figure 8) and highly effective observed antibacterial activity make them a very attractive form of silver administration.

Nanoparticle size

Martinez-Castanon et al. (2008) studied the effect of nanoparticle size on antibacterial effectiveness. To begin, nanoparticles with 7-nm, 29-nm, and 89-nm diameters were synthesized. The syntheses of the three different sized nanoparticles all used silver nitrate as a supply of silver ions and gallic acid as a reducing and stabilizing agent. The different sizes were produced by simply either altering the pH or irradiating the solutions with UV light. Transmission electron microscopy was used in the characterization of the nanoparticles to determine their average sizes (Figure 9).

Once the sizes of the nanoparticles were confirmed, MIC assays were performed on E. coli and S. aureus using the synthesized nanoparticles. The results of the MIC assays showed that smaller nanoparticles have more of an inhibitory effect than larger nanoparticles and that S. aureus is more resistant to silver nanoparticles than E. coli. The result that S. aureus is more resistant than E. coli to silver agrees with findings obtained by Kawahara et al. (2000).

Gallic acid was used as a control in the MIC assays (Figure 10); the silver nanoparticles were added to cell cultures in the MIC assays in the same solution in which they were produced, so it needed to be tested whether or not the gallic acid produced as a byproduct of the nanoparticle synthesis would have an effect on cell growth. For the MIC assay using E. coli, the difference between the minimum inhibitory concentration of the 29-nm nanoparticles and that of the 89-nm nanoparticles was statistically insignificant (Figure 10).

The increased antimicrobial activity of the smaller nanoparticles could be due to the fact that smaller particles have an easier time getting through the cell membrane and cell wall and that relative to larger nanoparticles, smaller particles have a greater surface area to volume ratio (Martinez-Castanon et al., 2008). The greater surface area to volume ratio of smaller nanoparticles means that per unit mass of silver, the smaller nanoparticles have more silver atoms in contact with the solution than do larger nanoparticles. For smaller nanoparticles, this means that more of the silver atoms contained in the nanoparticle are able to take part in cell destruction processes. If only the outer layer of silver atoms of a silver nanoparticle are able to be ionized to silver ions, then a few large nanoparticles should produce less silver ions than a lot of small nanoparticles. Because silver ions are what impart antibacterial properties to a given silver-containing material, it makes sense that smaller silver nanoparticles have more antimicrobial effectiveness than larger silver nanoparticles.

Nanoparticle shape

In addition to size, nanoparticle shape also plays a role in antibacterial activity. Pal et al. (2007) synthesized spherical, rod-shaped, and triangular silver nanoparticles and tested each of them for antimicrobial activity using E. coli. E. coli was streaked onto agar plates, and 1 µg, 12.5 µg, 50 µg, or 100 µg of each of the three types of synthesized silver nanoparticles as well as AgNO₃ were added to the streaked plates. The number of colonies that formed for each of the conditions was counted and graphs relating the number of formed colonies and silver concentration for each of the four types of silver tested were constructed (Figure 11). It was determined that the order of most antibacterial to least antibacterial of the four silver-containing compounds was triangular, spherical, rod-shaped, and AgNO₃. This order of antibacterial activity is explained by the different types of facets on the nanoparticles. The triangular nanoparticles had more active facets (electron dense facets) than did the spherical nanoparticles. The spherical nanoparticles, which weren’t perfectly spherical, had more active facets than the rod-shaped nanoparticles (Pal et al., 2007). Thus, shape does have an effect on antibacterial activity of silver nanoparticles and nanoparticles with more active facets have more antibacterial activity.

Toxicity

The only known side effect of high exposure to or ingestion of silver is argyria, a permanent condition where silver collects in the skin and other body tissues (Wikipedia: Argyria). Long-term ingestion of gram quantities silver, most times in the form of colloidal silver (Figure 12), is thought to be the cause of argyria (Silvestry-Rodriguez et al., 2007). Based on human case reports and animal experiments, 10 g of silver is thought to be the lifetime NOAEL (No Observable Adverse Effect Level) (World Health Organization 1996). Although argyria causes a blue-gray discoloration of the skin, it is not thought to be a health risk otherwise (ATSDR: Silver). Depending on the degree of seriousness, argyria could be socially debilitating for some individuals (Wikipedia: Argyria).

The EPA has established a secondary maximum contaminant level for silver of 0.1 mg/L (EPA: Secondary standards). These secondary maximum contaminant levels are unenforced and are merely provided as suggestions for the management of public water systems (EPA: Secondary standards). The reason for the non-enforcement of these secondary standards is that the contaminants for which these standards have been set all have been found to only cause aesthetic effects, which change the smell or taste of drinking water, cosmetic effects, which, as in the case of silver, are unwanted but not harmful to health, and technical effects, which may cause damage to water equipment (EPA: Secondary standards).

Current uses

Wound dressings

Novel wound dressings have been developed that use silver to help prevent wound infections. Silver nanoparticles are incorporated into the wound dressing, and the silver-enhanced wound dressings were found in vitro to consistently kill Pseudomonas aeruginosa cultures entirely and kill Staphylococcus aureus cultures with >99.99% efficiency (Ong et al., 2008). In mice, the silver-enhanced wound dressings were also found to reduce mortality from Pseudomonas aeruginosa wound infections from 90% to 14.3% (Ong et al., 2008).

Endotracheal tubes

Among hospital patients that require ventilator-assisted breating, ventilator-associated pneumonia is the most common illness (Olson et al., 2002). Endotracheal tubes are used by patients needing ventilator-assisted breathing. Silver coatings on the inside of endotracheal tubes have been shown to delay the appearance of bacteria on the insides of these tubes, and subjects that used the silver-coated tubes also showed decreased lung colonization by Pseudomonas aeruginosa (Olson et al., 2002). Kollef et al. (2008) showed that silver-coated endotracheal tubes actually do reduce the incidence or increase the onset time of ventilator-associated pneumonia in patients using a ventilator.

Surgical masks

Studies have examined the antibacterial properties of surgical masks coated with silver nanoparticles (Li et al., 2006). Nanoparticle coated masks were capable of a 100% reduction in viable E. coli and S. aureus cells after incubation. Additionally, the study reported no signs of skin irritation in any of the persons wearing the masks (Li et al., 2006).

Cotton fibers

Silver nanoparticles have been used to impart antimicrobial activity to cotton fibers. Cotton samples were immersed in silver nanoparticle solutions and then subjected to a curing process to allow the nanoparticles to adhere to the cotton (El-Rafie et al., 2010). A chemical binder was then applied to the fabric to help maintain nanoparticle-cotton binding. Cotton samples prepared in this manner were able to reduce S. aureus and E. coli cell counts by 97% and 91% respectively. Even after subjecting the fabric to 20 laundry cycles, the cotton samples were still able to reduce S. aureus and E. coli cell counts by 94% and 85% respectively (Figure 13). Cotton prepared in this manner could be used by individuals working in the medical field or those who often work with microbes to prevent the spread of infectious bacteria (El-Rafie et al., 2010).

Drinking water

Although chlorine has long been used as the primary drinking water disinfectant, it has been shown that the chlorination of water can lead to the formation of many hazardous compounds (Moudgal et al., 2000). Based on its low known toxicity to humans, silver has been suggested as a possible disinfectant of drinking water (Silvestry-Rodriguez et al., 2007). Water recycling systems on the Mir space station and NASA shuttles have used silver as an effective water disinfectant, and in the United States, faucet-mounted and pitcher home water purification units contain carbon filters that are supplemented with silver (Silvestry-Rodriguez et al., 2007).

Glass

AGC Flat Glass Europe has developed a glass with antimicrobial properties (AGC: Antibacterial glass). Silver ions incorporated into the glass are responsible for the antimicrobial activity. The company reports that 99.9% of bacteria that come in contact with the surface of the glass are killed. The glass was produced to help prevent the spread of pathogens in a hospital setting. It could also be used to maintain the integrity of sterile workspaces.

Food packaging

Various types of food packaging have been supplemented with silver-containing compounds to deter microbial growth and extend product shelf life. Some of these packaging types include bulk food storage containers, paperboard cartons, plastic or paper food wraps, and milk containers (Appendini and Hotchkiss, 2002). Silver zeolite is the silver-containing compound used in food packaging (Appendini and Hotchkiss, 2002). Although few silver-containing compounds are approved by the FDA for direct food contact, silver-incorporated food packaging is quite widespread in Japan (Appendini and Hotchkiss, 2002).

Conclusion

Recent studies have revealed that the antimicrobial properties of silver are due to its ionized form, Ag⁺, and its ability to cause damage to cells by interacting with thiol-containing proteins and DNA. These effects have been visualized (Feng et al., 2000) as well as quantified through many experiments. Silver nanoparticles are a form of silver of particular interest because of their easy production, high antimicrobial activity, and ability to be incorporated into a diverse range of products. With the ever increasing number of antibiotic-resistant strains of bacteria and silver’s low toxicity to humans, the use of silver as an antimicrobial agent is an exciting topic with a great deal of relevance to many fields of study and industry.

References

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Appendini, P. and Hotchkiss, J.H. „Review of antimicrobial food packaging.“ Innovative Food Science & Emerging Technologies. 2002. Volume 3, issue 2. p. 113-126.

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Breck D.W. Ion exchange reactions in zeolites, zeolite molecular sieves, structure, chemistry and use, New York: Wiley, 1974. p. 529.

Davies, R.L. and Etris S.F. „The Development and Functions of Silver in Water Purification and Disease Control.“ Catalysis Today. 1997. Volume 36. p. 107–114.

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Feng, Q.L., Wu, J., Chen, G.Q., Cui, F.Z., Kim, T.N., Kim, J.O. „A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus.“ Journal of Biomedical Materials Research Part A. 2000. Volume 52, issue 4. p. 662-668.

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Kollef. M.H, Afessa, B., Anzueto, A., Veremakis, C., Kerr, K.M., Margolis, B.D., Craven, D.E., Roberts, P.R., Arroliga, A.C., Hubmayr, R.D., Restrepo, M.I., Auger, W.R., Schinner, R. „Silver-Coated Endotracheal Tubes and Incidence of Ventilator-Associated Pneumonia.“ The Journal of the American Medical Association. 2008. Volume 300, No. 7. p. 805-813.

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PPM of colloidal silver needs to be understood in its entirety.  PPM means parts per million.  By definition 1 PPM is 1 milligram of silver deposited in 1 liter of water (1,000 ml) (1,000,000 mg).  If one were to ingest that 1 mg. piece of silver, it would not do much good.  If you were to divide that 1 mg. into 1,000,000 particles of silver, it would then have much more efficacy because it takes one particle of silver to disable 1 pathogen.  The silver is now 1,000,000 times better than 1 piece of silver even though by definition it is still only 1 PPM.  If one were to further divide the 1 mg piece of silver into 100,000,000  particles, it would be very beneficial indeed.  And so as the silver is more finely divided the PPM by definition remains the same.

So, what really counts is not how many PPM the silver is but how many particles the silver has been divided into,  That is why it isn’t necessary to have high PPM but it IS important to divide the silver as finely as possible.  To see how small the silver can be divided by our colloidal silver generators,  please look at the electron microscope photos.  It is not better to try to take high PPM colloidal silver but to take CS that is properly made.  If you think more silver is necessary, just take more of better made low PPM colloidal silver and you will be further ahead than if you took poorly made, high PPM colloidal silver. 

Another factor is the form silver is in.  90-95% of the silver made with the SG6 Auto is ionic and up to 98% of the SG7 Pro silver water is ionic.  Ionic silver is like sugar or salt dissolved into the water.  It is invisible and can only be sensed with a test meter such as the PWT we sell.  Ionic silver is conductive whereas colloidal silver is not.  Colloids are like small ball bearings floating around in the water and separated from each other by what is called Brownian Motion.  They carry no electrical charge.  The ions are silver atoms missing one electron in the outer shell and therefore are positive in charge.  The ionic portion is evenly dispersed like dissolved sugar or salt.

The generator determines the shutoff point by measuring the ionic water conductivity.  

If the colloidal silver is properly made it will be crystal clear.  This is because the particles are too small to reflect any light.  If it shows any color, the particles are too large.  The first color seen is yellow.  As the particle size increases other colors such as red, green, blue, brown or black may be seen.  Any color seen will indicate CS that is not very good.  

Colloidal silver has been around a long time.  It was used extensively in the 20th century until antibiotics became popular and relegated the use of silver in general to relative obscurity.  Colloidal silver wasn’t patentable; drugs were.  Profits were made in selling a patented product.  And some silver compounds had side effects if used improperly.  They could cause argyria, a cosmetic skin condition which could cause the skin to turn a blue/gray color. 

With the present day problems of bacteria becoming resistant to antibiotics, colloidal silver is making a resurgence in popularity and use.   One of the reasons for the renewed interest is the fact that bacteria and viruses are not resistant to contact with silver.   Colloidal silver may be the magic bullet for mankind if antibiotics are no longer useful.   Colloidal silver was used to cure and/or treat many diseases before being replaced with antibiotics.

What was thought to be the end of infectious diseases was accomplished in the 1940’s. With the advent of penicillin, they were thought to be a problem of the past. How wrong they were!

It turned out that many bacteria were able to breed new and more powerful strains that were resistant to the „new“ antibiotics over time. By the 1990’s it was obvious that antibiotics were not going to take care of our infectious diseases. Some diseases which were becoming resistant were various strains of Pneumococcus, Tuberculosis and Gonorrhea to mention a few.

40,000 to 50,000 Americans will die from Streptococcus pneumoniae each year. And it’s not the drug resistant strain that’s doing the killing. It’s the regular strain. What’s going to happen when the drug resistant strain hits us? It will be worse than you can imagine. This disease can manifest in many ways. It can cause middle ear infection in children besides causing death in older persons. It’s responsible for half the visits to pediatricians each year. It is the major cause of middle ear infections in children. It’s also a major cause of death in older persons.

Staphylococcus aureus is another disease that is taking over the hospitals in America. There are many strains and some are drug resistant to almost all antibiotics. There is apparently only one antibiotic left that works, Vancomycin. When that one quits working, what will be left to the doctors arsenal? Not much. Another strong antibiotic is Methycillin.  Staph is now becoming resistant to it and is called MRSA (Methicillin Resistant Staphylococcus Aureas).

One of the real problems has been that patients ask for and sometimes get antibiotics when they aren’t called for, such as for the common cold and other viral infections. This has led to the proliferation of these drug resistant strains of bacteria. Viruses don’t respond to antibiotics, so prescribing them is futile and should not be done, but it is used by too many doctors. Sometimes to pacify patients, sometimes to second guess the problem. It’s called the „shotgun“ approach. Throw whatever you’ve got at the problem and maybe you’ll hit the target. Sometimes it works; sometimes it doesn’t. We can blame the problem on too much use of antibiotics when they are not called for.

Drug resistant strains of these, and other bacteria are becoming more commonplace. It is only a matter of time until we have diseases we cannot control.

Colloidal silver is the drug that may be our best bet for surviving these terrible diseases. It is so powerful that bacteria, viruses and even some fungi can not live in contact with colloidal silver over 6 minutes.

Silver has been used for healing for centuries. The Greeks and Romans kept liquids in silver jars. During the plagues in Europe, many royal families escaped disease because they ate off silver plates and used silver utensils. It was used by the American pioneers to keep water and milk from spoiling or becoming contaminated. It is used by NASA to purify water in the space shuttle. Russia also uses it in their space shuttle. It is used by some airlines to purify water on flights. Thin silver foil is still used in India and China to wrap portions of food in. The food and silver wrap are eaten together. Silver is used in most of the burn centers in the U.S. and has been used to prevent blindness in newborn infants eyes for many years.

Der Begriff „Kolloid“ bezeichnet die Mischung zweier Substanzen verschiedener Aggregatzustände, fest (Silberatome) und flüssig (destilliertes Wasser). Dabei liegt bei einer Dichte von 15 ppm das Silber in extrem kleinen Partikeln von ca. 25 – 35 Atomen (Cluster-Größe) vor. Kolloide sind die kleinsten Teilchen, in die Materie unter normalen Bedingungen zerlegt werden kann, ohne dass die individuellen Eigenschaften dabei verloren gehen. Die nächste Stufe der Zerkleinerung wäre das einzelne Atom selbst. Diese Silber Partikel befinden sich in reinem destillierten Wasser und tragen eine elektrische Ladung. Da sich gleiche Ladungen gegenseitig abstoßen, halten sich die Teilchen so in Schwebe. Sie sind im Wasser optimal verteilt und setzen sich nicht am Boden der Flasche ab.

Diese wichtige elektrische Ladung geht allerdings wie bei einer Batterie mit der Zeit – vor allem durch Lichteinfluss und störende elektromagnetische Strahlungen verloren. Deshalb sollte kolloidales Silber immer lichtgeschützt und fern von elektrischen Geräten aufbewahrt werden. Am wirkungsvollsten ist kolloidales Silber in einem Zeitraum von drei bis vier Monaten nach der Produktion. Produkte die älter als 3 bis 4 Monate sind, verlieren dann schnell ihre hohe Wirksamkeit.

Eigenschaften

Kolloidales Silber hatte bereits vor hundert Jahren eine große medizinische Bedeutung, geriet aber mit der Einführung von Antibiotika zunehmend in Vergessenheit.
Heute erfährt kolloidales Silber eine große Renaissance.

Kolloidales Silber ist ein äußerst wirkungsvolles Antibiotikum mit folgenden Vorteilen:
– Kolloidales Silber wirkt gegen 650 verschiedene Erreger. Antibiotika dagegen nur gegen vielleicht ein Dutzend Bakterien.
Gegen Viren wirkt Antibiotika überhaupt nicht!

Tatsächlich wird jeder bisher getestete Erreger innerhalb von 3 – 4 Minuten abgetötet, bei einer Konzentration von nur
5mg Silber / Liter Wasser. Resistente Erreger wurden bisher nicht entdeckt.
– Kolloidales Silber wirkt auch bei Erregern die gegen Antibiotika resistent sind!
– Kolloidales Silber erzeugt selber keine Resistenzen.
– Kolloidales Silber ist frei von Nebenwirkungen.

Wirkung

Nach medizinischen Fachzeitschriften aus der ganzen Welt, ist kolloidales Silber ein wirkungsvolles Breitband-Antibiotikum und tötet alle einzelligen Parasiten, also Bakterien, Viren und Pilze, in kürzester Zeit ab.
Einzellige Parasiten benötigen für ihren Stoffwechsel ein bestimmtes Enzym, das durch kolloidales Silber blockiert wird. Der Stoffwechsel der Parasiten kommt zum Erliegen und sie sterben in einer Zeit von höchstens 6 Minuten nach Kontakt mit dem Silber ab. Gesunde Hautzellen und gesundheitsfördernde Bakterien sollen bei der Behandlung mit kolloidalem Silber nicht geschädigt werden, unterstützend können jedoch während und nach einer oralen Silberkur die Darmflora aufbauende Mittel eingenommen werden. Ein weiterer Vorteil von kolloidalem Silber ist, dass die Krankheitserreger nicht resistent werden.

Kommentare aus amerikanischen Fachzeitschriften

Health Consciousness (Vol. 15 No. 4):

„Es steht nicht in Konflikt mit irgendeiner anderen Medikation und führt auch nicht zu Magenbeschwerden. Tatsächlich ist es eine Verdauungshilfe. Es brennt nicht in den Augen. Medizinjournal – Berichte und dokumentierte Studien der letzten 100 Jahre sprechen von keinen Nebenwirkungen durch oral oder intravenös verabreichtem Silberkolloid, weder bei Tieren noch bei Menschen. Es wurde mit hervorragenden Ergebnissen bei hochakuten Gesundheitsproblemen eingesetzt. Ohne übertreiben zu wollen: Es ist an der Zeit, kolloidales Silber nicht nur als sicherste, sondern auch als wirksamste Medizin der Welt anzuerkennen“.

Perceptions Magazine (Mai/Juni 1996):

Renaissance der Kolloidforschung: „Um die Jahrhundertwende (1900!) gelang Wissenschaftlern ein bedeutender Durchbruch in der Medizin: Die wichtigsten Körperflüssigkeiten (Blut, Lymphflüssigkeit) sind
Kolloide. Dies eröffnete unbegrenzte Möglichkeiten. Doch mit synthetisierten Antibiotika war mehr Geld zu verdienen. Die heutige Krise im Gesundheitswesen und die immer weiter abnehmende Wirksamkeit von Antibiotika lenkt den Blick zurück auf die Kolloide – insbesondere auf die extrem vielseitigen Anwendungsmöglichkeiten von kolloidalem Silber. Antibiotikaresistente Erreger lösen in den Vereinigten Staaten ganze Epidemien aus. So absurd es klingt – die dritthäufigste Krankheits- und Todesursache in den Vereinigten Staaten ist heute wieder die Infektionskrankheit.“

Exotic Research Report (Vol. 1/1) auf englisch:

Dr. Robert C. Becker?
Nach Dr. 0. Becker bekannter Biomedizinforscher, sterben alle pathogenen Mikroorganismen, die gegen Antibiotika bereits immun sind, durch Verabreichung von kolloidalem Silber ab.
Der Pharmakologe Barnes erklärt: „Viele Arten von Mikroben, Viren und Pilzen werden durch den Kontakt mit kolloidalem Silber abgetötet und können nicht mehr mutieren. Doch schädigt es nicht Hautzellen-Enzyme oder freundliche Bakterien. Anders als Antibiotika, schwächt kolloidales Silber nicht das Immunsystem. Tatsächlich führt es zu einer außerordentlichen Kräftigung des Immunsystems.
Dr. Becker erkannte einen Zusammenhang zwischen niedrigen Silberanteilen und Krankheiten. Der durchschnittliche Anteil im Körper beträgt 0,001%. Er behauptet, ein Absinken dieses Wertes sei verantwortlich für die Fehlfunktionen des Immunsystems. Es scheint als ob etwas im Silber eng mit dem grundlegenden Lebensprozeß verbunden ist. Dr. Becker berichtet über Erfahrungen mit älteren Patienten: „Silber hat mehr bewirkt, als nur Krankheitserreger abzutöten. Es förderte in besonderer Weise das Knochenwachstum und beschleunigte die Heilung von verletztem Gewebe um mehr als 50%-. Er fand heraus., daß „Silber einen tiefgreifenden Heilstimulus für Haut und anderes zartes Gewebe bewirkt, anders als bei jedem natürlichen Vorgang…“ und daß es eine neue Art des Zellwachstums fördert, die aussieht wie die Zellen von Kindern! Diese Zellen wachsen schnell und produzieren dabei eine erstaunliche Sammlung primitiver Zellformen, die in der Lage sind, sich mit hoher Geschwindigkeit zu multiplizieren und sich dann in die spezifischen Zellen eines Organs oder eines verletzten Gewebes zu differenzieren, selbst bei Patienten über 50 Jahren. Dr. Becker entdeckte sogar, daß kolloidales Silber Krebszellen in normale Zellen zurückverwandeln kann.

 

Anwendung des kolloidalen Silbers

Kolloidales Silber ist innerlich und äußerlich anzuwenden.

Die äußere Anwendung eignet sich für Akne, Warzen, offene Wunden, Herpes, Schuppenflechte, Fußpilz und ähnlichen Hauterkrankungen. Dabei können die betroffenen Stellen mit einem in kolloidalem Silber getränkten Wattebausch eingerieben werden. Bei Warzen, Schnitt- und Schürfwunden empfiehlt sich auch das Anlegen eines Verbandes.

Für eine innere Anwendung, etwa bei Darmbeschwerden, Grippe, Candidabefall, chronischer Müdigkeit oder auch zur Ausleitung von Quecksilber durch Amalgam-Zahnfüllungen, wird kolloidales Silber in Wasser verschüttelt und dieses Wasser über den Tag verteilt getrunken.

Bei Schnupfen, Mandelentzündung, Bindehautentzündung einfach mit einer Lösung gurgeln, spülen oder als Tropfen verwenden. Weitere Anwendungsmöglichkeiten sind vaginale und rektale Spülungen, aber auch Nasen- und Inhalationssprays.

Übrigens ist kolloidales Silber ein hervorragendes Pflanzenschutzmittel oder zur Behandlung von Tieren geeignet.

Bei diesen Krankheiten ist die Anwendung von kolloidalem Silber erfolgreich. Dabei ist jeweils der erlaubte therapeutische Rahmen zu beachten (und die ärztliche Sorgfaltspflicht!)

Virale und bakterielle Erkrankungen

Grippe, grippale Infekte
Durchfall, Gastritis, Ruhr
Salmonelleninfektion
Candidamykosen
Chronische Müdigkeit
Lungenentzündung
Tuberkulose, Keuchhusten
Alle Arten von Entzündungen im Körper
Verbrennungen
Sonnenbrand
Mückenstiche
Offene Wunden
Blutvergiftung (Lymphangitis)
Malaria, Rheuma, Arthritis
Akne, Warzen
Herpes (simples und zoster)
Fußpilz, Schuppenflechte
Furunkel, Dermatitis
Geschlechts-Krankheiten

Weitere Anwendungen finden Sie in dem Buch über kolloidales Silber:

Das kolloidale Silber ist ein „Experimentierwasser“ und kein Arzneimittel im Sinne des AMG. Bei gesundheitlichen Problemen wenden Sie sich bitte an Ihren Arzt oder Heilpraktiker. Es kann zu Entgiftungserscheinungen und zur Anregung des Stoffwechsels kommen.
Von der trinkfertigen Lösung, die Sie selber herstellen, können Sie bis zu 3 Gläser täglich zu sich nehmen.

Was kann es nicht? Grenzen und Nebenwirkungen
Jede Therapie, die mentale und psychische Aspekte in ihrer Behandlung nicht berücksichtigt, kann auf Dauer nur Teilerfolge erzielen. Insofern ist auch kolloidales Silber kein Allheilmittel, das die bewusste Auseinandersetzung mit der Krankheit und den eigenen Lebensumständen überflüssig macht.

Kritische Stimmen meinen, bei einer Langzeitanwendung von höher dosierten Silberpräparaten könnte es zu Ablagerungen in Haut, Augen und inneren Organen kommen, allerdings ist dazu insgesamt eine Menge von 3,8g elementarem Silber nötig. Bei der Einnahme von kolloidalem Silber liegt für Erwachsene die empfohlene Tagesdosis bei höchstens 5 mg (Mikrogramm, ein Millionstel) pro Kilogramm Körpergewicht. Es ist also in jedem Fall empfehlenswert, sich an die Dosierungsvorgaben zu halten. Und da kolloidales Silber schon in geringsten Mengen wirkt, gilt für die Dosierung ohnehin „weniger ist mehr“.

Einige Mitarbeiter der amerikanischen Gesundheitsbehörden verweisen auf die Gefahr der Argyrie (schieferfarbene Hautverfärbung) – dies gilt allerdings nicht für kolloidales Silber. Argyrie hat sich bisher nur bei Personen gezeigt, die über Jahrzehnte Silberproteine (also kein reines Silber) zu sich genommen haben. Eine durch kolloidales Silber hervorgerufene Argyrie ist nicht bekannt

Bisher sind Nebenwirkungen nicht bekannt. Als Erst-Reaktion können sich die Beschwerden kurzfristig verschlechtern, aber auch Begleiterscheinungen wie etwa Müdigkeit oder Schüttelfrost klingen nach zwei bis drei Tagen wieder ab. In seltenen Fällen reagieren Patienten anfänglich auch mit Stimmungsschwankungen oder mit leichter Übelkeit.